OSIMERT(Osimetirib 80mg)

10200.0 आईएनआर/Bottle

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Osimert 80 mg is indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, whose disease has progressed on or after EGFR tyrosine kinase inhibitor (TKI) therapy.Side Effects of Osimert 80 mgCommon side effects are Interstitial Lung Disease or Pneumonitis, QTc Interval Prolongation, Cardiomyopathy, KeratitisPregnancy & LactationUse in Pregnancy: There are no or limited amount of data from the use of Osimert 80 mg in pregnant women. Studies in animals have shown reproductive toxicity. Based on its mechanism of action and preclinical data, Osimert 80 mg may cause foetal harm when administered to a pregnant woman. Administration of Osimert 80 mg to pregnant rats was associated with embryolethality, reduced foetal growth and neonatal death at exposures similar to what is expected in humans. Osimert 80 mg is not recommended during pregnancy and in women of childbearing potential not using contraception.Use in Lactation: It is not known whether Osimert 80 mg or its metabolites are excreted in human milk. Administration to rats during gestation and early lactation was associated with adverse effects, including reduced growth rates and neonatal death. There is insufficient information on the excretion of Osimert 80 mg or its metabolites in animal milk. A risk to the suckling child cannot be excluded. Breast-feeding should discontinue during treatment with Osimert 80 mg.Fertility: There are no data on the effect of Osimert 80 mg on human fertility. Results from animal studies have shown that Osimert 80 mg has effects on male and female reproductive organs and could impair fertility